The cancer stem cells share many characteristics with normal stem cells, including self-renewal and differentiation.
With the growing evidence that cancer stem cells exist in a wide arrayof tumors, it is becoming increasingly important to understandthe molecular mechanisms that regulate self-renewal and differentiationbecause corruption of genes involved in these pathways likely participates in tumor growth.
This new paradigm of oncogenesis has been validated in a growing list of tumors. Studies of normaland cancer stem cells from the same tissue have shed light on theontogeny of tumors. That signaling pathways such as Bmi1 and Wnt have similar effects in normal and cancer stem cell self-renewal suggests that common molecular pathways regulate both populations.Understanding the biology of cancer stem cellswill contribute to theidentification of molecular targetsimportant for future therapies.
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Defining the Molecular Determinants of Myogenic Commitment Michael Rudnicki's laboratory uses molecular genetic approaches to determine the function and roles of genes that regulate cellular proliferation and differentiation of stem cells. They identified Pax7 as a transcription factor required for the specification of satellite cells and identified Wnt signaling as playing an important role in the myogenic specification of adult stem cells. In adult skeletal muscle, satellite cells reside beneath the basal lamina of muscle, closely juxtaposed to muscle fibers, and make up 2-7 percent of the nuclei associated with a particular fiber. Satellite cells are normally mitotically quiescent but are activated (they enter the cell cycle) in response to stress induced by weight bearing or by trauma. The descendants of activated satellite cells, called myogenic precursor cells, undergo multiple rounds of division before fusion and terminal differentiation. Source: |
muscle stem cells lacking the MyoD
gene after transplantationinto
regenerating skeletal muscle
MyoD is a myogenic master transcription factor that plays an essential role in muscle satellite cell (muscle stem cell) differentiation. To further investigate the function of MyoD in satellite cells, we examined the transplantation of satellite cell-derived myoblasts lacking the MyoD gene into regenerating skeletal muscle.
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ScienCentral News Video
with fast genetic diagnostics
Names of vodeos (left to right):
1)Gliadel Wafer Mechanism
2)Brain Tumor (Glioblastoma)
Treatment with GEMM
3)The Estrogen Receptor (I):
Hormonal Mechanisms in the Body
4)Organic Chemistry Lab Demo:
Extractions (short version)
5)Sirtris and Harvard
Discover New Mechanism to Slow Aging
6)Micro and nanotechnologies
are revolutionising medicine
Science Meets Politics and Ethics
cells' true source
Explanation
- August 2007 - part 1
Names of vodeos (left to right):
1)Health Matters: Fertility
and In Vitro Fertilization (IVF)
2)Proteins: Assemblies in Action
3)Profiles in Discovery:
Russell Doolittle
4)Cardiovascular Update:
Coronary Artery Plaques
5)Stem Cells: The Brain's
Beginnings
6)Health Matters:
Stem Cell Research
(FROM 8/7/01)
in Cancer Treatment II
for Genetic Testing
What is a Chalazion?
A chalazion is a tiny lump of the upper or lower eyelid caused by inflammation of a gland of the lid. It may be soft and fluid-filled or firmer. A chalazion is also referred to as a meibomian cyst, tarsal cyst, or conjunctival granuloma.
What are these eyelid glands?
Eyelid glands are called the meibomian glands. They are also known as the palpebral glands, tarsal glands, or tarsoconjunctival glands. There are 30 to 40 of these glands in each of the upper and lower lids. The tiny openings of each of these oil or sebaceous glands are just behind the lid lashes at the lid margins. These glands produce a thick liquid secretion that is discharged into the tear film of the eye. This liquid is a mixture of oil and mucus and is called sebum. The liquid acts to lubricate the surface of the eye.
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From Wikipedia, the free encyclopedia
شالازیون از ریشه یونانی و به معنای "توده کوچک "است و اندازه آن می تواند از ته سنجاق تا یک نخود درشت متفاوت باشد
se recuperan
Dr. Lipton began his scientific career as a cell biologist. He received his Ph.D. Degree from the University of Virginia at Charlottesville before joining the Department of Anatomy at the University of Wisconsin’s School of Medicine in 1973. Dr. Lipton’s research on muscular dystrophy, studies employing cloned human stem cells, focused upon the molecular mechanisms controlling cell behavior. An experimental tissue transplantation technique developed by Dr. Lipton and colleague Dr. Ed Schultz and published in the journal Science was subsequently employed as a novel form of human genetic engineering.
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a Form of Creation
Potential for Health
Dr. Bruce Lipton explains
how we are not limite
and Lung Transplantation
rama de la Genética
